SCHEMBL27369844

SCHEMBL27369844

CC(C)c1ccc(-c2n[nH]cc2C(=O)NC(CC(N)=O)c2cccc(Cl)c2)c(F)c1

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DCAF1 Q9Y4B6 16/20 0.59
PDPK1 O15530 1/20 0.42
CTSA P10619 1/20 0.42
CNR2 P34972 1/20 0.41
MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26470124 1.00 DCAF1 (0.59) DCAF1PDPK1CTSACNR2MAPK1
SCHEMBL27278326 0.89 DCAF1 (0.58) DCAF1CTSACNR2MAPK1
SCHEMBL27278325 0.84 DCAF1 (0.56) DCAF1CTSACNR2MAPK1
SCHEMBL27369836 0.83 DCAF1 (0.53) DCAF1CTSACNR2MAPK1
SCHEMBL26795041 0.74 DCAF1 (0.66) DCAF1CTSAMAPK1
SCHEMBL27278324 0.72 DCAF1 (0.63) DCAF1CTSAMAPK1
SCHEMBL27369934 0.72 DCAF1 (0.48) DCAF1CTSACNR2MAPK1
SCHEMBL27369861 0.72 DCAF1 (0.65) DCAF1CTSAMAPK1
SCHEMBL26795044 0.70 DCAF1 (0.65) DCAF1CTSAMAPK1
SCHEMBL27369904 0.69 DCAF1 (0.51) DCAF1CTSACNR2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024092011-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-05-02 WO disclosed