Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B13 | Q7Z5P4 | 11/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595779 | 0.88 | HSD17B13 (0.41) | HSD17B13ADORA2ACYP1A2 | |
| SCHEMBL24665500 | 0.85 | HSD17B13 (0.44) | HSD17B13 | |
| SCHEMBL7274815 | 0.82 | PDE4A (0.39) | PDE4AADORA2AADORA2BPDE4BPDE4C | |
| SCHEMBL5487196 | 0.79 | HSD17B13 (0.47) | HSD17B13 | |
| SCHEMBL5610519 | 0.79 | HSD17B13 (0.43) | HSD17B13 | |
| SCHEMBL13947776 | 0.79 | HSD17B13 (0.43) | HSD17B13 | |
| SCHEMBL9120735 | 0.79 | HSD17B13 (0.40) | HSD17B13PDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL2347364 | 0.77 | ADORA2B (0.45) | HSD17B13ADORA2B | |
| SCHEMBL18686733 | 0.77 | TYR (0.41) | PDE4AADORA2AADORA2BPDE4BPDE4C | |
| SCHEMBL2456869 | 0.76 | ALDH1A1 (0.46) | HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |