Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B13 | Q7Z5P4 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RGS4 | P49798 | 1/20 | 0.39 |
| ▸ | RGS8 | P57771 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370892 | 0.88 | HSD17B13 (0.43) | HSD17B13CYP1A2ADORA2A | |
| SCHEMBL24665500 | 0.82 | HSD17B13 (0.44) | HSD17B13ALDH1A1 | |
| SCHEMBL2347364 | 0.81 | ADORA2B (0.45) | HSD17B13DRD2DRD3 | |
| SCHEMBL27362845 | 0.79 | ALDH1A1 (0.47) | ALDH1A1NPSR1POLBKMT2ARGS4 | |
| SCHEMBL19359494 | 0.78 | TSHR (0.50) | HSD17B13ALDH1A1POLBKMT2ALMNA | |
| SCHEMBL4551700 | 0.77 | TLR8 (0.41) | ALDH1A1NPSR1POLBLMNATSHR | |
| SCHEMBL18357379 | 0.76 | HSD17B13 (0.39) | HSD17B13DRD2DRD3 | |
| SCHEMBL19359478 | 0.76 | FAAH (0.49) | POLBLMNATSHRTDP1L3MBTL1 | |
| SCHEMBL5610519 | 0.76 | HSD17B13 (0.43) | HSD17B13 | |
| SCHEMBL13947776 | 0.76 | HSD17B13 (0.43) | HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637965-B1 | ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES | ISIS PHARMACEUTICALS INC (US) | 2002-10-16 | — | — | EP | claimed |