Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27437403 | 0.75 | CES2 (0.41) | TSHRCES2CES1CHRM2CHRM4 | |
| SCHEMBL5986995 | 0.73 | TSHR (0.39) | TSHRCES2CES1LMNACHRM2 | |
| SCHEMBL7786786 | 0.73 | TSHR (0.39) | TSHRCES2CES1LMNACHRM2 | |
| SCHEMBL27808530 | 0.72 | ALDH1A1 (0.36) | TSHRCES2CES1LMNA | |
| SCHEMBL1911562 | 0.72 | CES2 (0.46) | TSHRCES2CES1LMNAGAA | |
| SCHEMBL7795103 | 0.72 | SMN1; SMN2 (0.40) | TSHRCES2CES1LMNACHRM2 | |
| SCHEMBL7601928 | 0.72 | SMN1; SMN2 (0.40) | TSHRCES2CES1LMNACHRM2 | |
| SCHEMBL5986993 | 0.72 | SMN1; SMN2 (0.40) | TSHRCES2CES1LMNACHRM2 | |
| SCHEMBL4677963 | 0.72 | CYP19A1 (0.44) | TSHRLMNACHRM2CHRM4CHRM1 | |
| SCHEMBL10781626 | 0.72 | TSHR (0.38) | TSHRCES2CES1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080720-C | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2002-03-13 | — | — | CN | disclosed |
| CN-1224718-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 1999-08-04 | — | — | CN | disclosed |