Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024803 | 1.00 | LMNA (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL12164090 | 1.00 | LMNA (0.67) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL10269569 | 0.90 | LMNA (0.54) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL15984263 | 0.90 | LMNA (0.54) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL16464726 | 0.87 | ESR1 (0.62) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL14652477 | 0.87 | ESR1 (0.62) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL10356189 | 0.84 | LMNA (0.56) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL24946437 | 0.84 | ESR1 (0.65) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL3370638 | 0.84 | ESR1 (0.65) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL12164276 | 0.84 | ESR1 (0.65) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088758-B2 | 17β-hydroxysteroid dehydrogenase type I inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2012-01-03 | — | — | US | disclosed |
| US-8088758-B2 | 17β-hydroxysteroid dehydrogenase type I inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2012-01-03 | — | — | US | disclosed |
| EP-1685150-B1 | NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | SOLVAY PHARM GMBH (DE) | 2008-09-03 | — | — | EP | disclosed |
| US-6881728-B1 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens | AKZO NOBEL N.V. (NL) | 2005-04-19 | — | — | US | disclosed |
| EP-1163259-B1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL NV (NL) | 2002-11-20 | — | — | EP | disclosed |
| EP-1163259-A1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | Akzo Nobel N.V. (NL) | 2001-12-19 | — | — | EP | disclosed |
| US-6136800-A | STEROIDS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-10-24 | — | — | US | disclosed |
| WO-2000053619-A1 | 14.BETA., 17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL N.V. (NL) | 2000-09-14 | — | — | WO | disclosed |
| US-6018062-A | SUCH AS 17-DIFLUOROMETHYLENE-ESTRA-1,3,5(10)-TRIEN-3-OL; USE AS ANTIOXIDANTS AND VASCULOPROTECTIVE AGENTS AS THEY CAUSE VASODILATOR NITROGEN OXIDE RELEASE AND PREVENT OXIDATION OF LDL CHOLESTEROL | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| EP-0712412-B1 | 15,15-DIALKYL-SUBSTITUTED DERIVATIVES OF ESTRADIOL | SCHERING AG (DE) | 1999-01-07 | — | — | EP | disclosed |
| US-5656622-A | 15,15-dialkyl-substituted derivatives of estradiol | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-08-12 | — | — | US | disclosed |
| US-5587496-A | HIGH ESTROGENIC EFFECTIVENESS; CAN BE USED FOR TREATING ESTROGEN DEFICIENCY SYMPTOMS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-12-24 | — | — | US | disclosed |
| WO-1995004070-A1 | 15,15-DIALKYL-SUBSTITUTED DERIVATIVES OF ESTRADIOL | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-02-09 | — | — | WO | disclosed |