Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.65 |
| ▸ | SHBG | P04278 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.65 |
| ▸ | STS | P08842 | 3/20 | 0.65 |
| ▸ | PGR | P06401 | 3/20 | 0.65 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.65 |
| ▸ | AR | P10275 | 3/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | SNCA | P37840 | 3/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.65 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164276 | 1.00 | ESR1 (0.65) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL24946437 | 1.00 | ESR1 (0.65) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL15965511 | 0.88 | STS (0.49) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL12164090 | 0.84 | LMNA (0.67) | ESR1ESR2HSD17B10LMNAHSD17B1 | |
| SCHEMBL5024803 | 0.84 | LMNA (0.67) | ESR1ESR2HSD17B10LMNAHSD17B1 | |
| SCHEMBL2738485 | 0.84 | LMNA (0.67) | ESR1ESR2HSD17B10LMNAHSD17B1 | |
| SCHEMBL2360694 | 0.83 | ESR1 (0.54) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL15984263 | 0.83 | LMNA (0.54) | ESR1ESR2LMNAHSD17B1STS | |
| SCHEMBL10269569 | 0.83 | LMNA (0.54) | ESR1ESR2SHBGHSD17B10LMNA | |
| SCHEMBL11683892 | 0.83 | AKR1C3 (0.52) | ESR1ESR2SHBGHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11633406-B2 | Industrial process for the preparation of high purity estetrol | RICHTER GEDEON NYRT. (HU) | 2023-04-25 | — | — | US | disclosed |
| WO-2023001866-A1 | PROCESSES FOR THE PREPARATION OF ESTETROL AND INTERMEDIATES THEREOF | NEWCHEM S.P.A. (IT) | 2023-01-26 | — | — | WO | disclosed |
| EP-3877395-B1 | INDUSTRIAL PROCESS FOR THE PREPARATION OF HIGH PURITY ESTETROL | RICHTER GEDEON NYRT (HU) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021044302-A1 | INDUSTRIAL PROCESS FOR THE PREPARATION OF HIGH PURITY ESTETROL | RICHTER GEDEON NYRT. (HU) | 2021-03-11 | — | — | WO | disclosed |
| US-20180265540-A1 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | DONESTA BIOSCIENCE B.V. (NL) | 2018-09-20 | — | — | US | disclosed |
| US-10000524-B2 | Synthesis of estetrol via estrone derived steroids | DONESTA BIOSCIENCE B.V. (NL) | 2018-06-19 | — | — | US | disclosed |
| WO-2017211330-A1 | 15β-SUBSTITUTED ESTRONE DERIVATIVES AS SELECTIVE INHIBITORS OF 17β-HYDROXYSTEOID-DEHYDROGENASES, METHOD OF PREPARATION AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2017-12-14 | — | — | WO | disclosed |
| US-20150105362-A1 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | PANTARHEI BIOSCIENCE B.V. (NL) | 2015-04-16 | — | — | US | disclosed |
| EP-1562976-B1 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | PANTARHEI BIOSCIENCE BV (NL) | 2010-05-26 | — | — | EP | disclosed |
| US-20060211669-A1 | Synthesis of estetrol via estrone derived steroids | DONESTA BIOSCIENCE B.V. (NL) | 2006-09-21 | — | — | US | disclosed |
| EP-1562976-A2 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | Pantarhei Bioscience B.V. (NL) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004041839-A2 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | PANTARHEI BIOSCIENCE B.V. (NL) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265540-A1 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | CYP19A1, HSD17B11, CYP17A1 | ESR1 6/4885ESR2 19/4885SHBG 50/4885 |
| US-11633406-B2 | Industrial process for the preparation of high purity estetrol | CYP17A1, HSD3B2, HSD3B1 | ESR1 106/4885ESR2 98/4885SHBG 146/4885 |
| US-20150105362-A1 | SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS | CYP19A1, HSD17B11, CYP17A1 | ESR1 6/4885ESR2 19/4885SHBG 50/4885 |
| US-20060211669-A1 | Synthesis of estetrol via estrone derived steroids | CYP19A1, HSD17B11, CYP17A1 | ESR1 9/4885ESR2 21/4885SHBG 42/4885 |
| US-10000524-B2 | Synthesis of estetrol via estrone derived steroids | CYP19A1, HSD17B11, CYP17A1 | ESR1 6/4885ESR2 19/4885SHBG 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.