Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | CTSL | P07711 | 6/20 | 0.40 |
| ▸ | CTSK | P43235 | 5/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684458 | 0.89 | CTSS (0.43) | CTSSEPHX2CTSLCTSKEPHX1 | |
| SCHEMBL681452 | 0.87 | CTSS (0.43) | CTSSEPHX2CTSLCTSK | |
| SCHEMBL2739250 | 0.85 | TRPV1 (0.41) | CTSSEPHX2 | |
| SCHEMBL681766 | 0.84 | CTSS (0.41) | CTSSEPHX2CTSLCTSK | |
| SCHEMBL2738631 | 0.84 | EPHX2 (0.44) | EPHX2 | |
| SCHEMBL2738500 | 0.81 | FPR2 (0.40) | — | |
| SCHEMBL2738590 | 0.81 | AKT3 (0.48) | — | |
| SCHEMBL12323872 | 0.81 | AKT3 (0.48) | — | |
| SCHEMBL12294178 | 0.81 | AKT1 (0.38) | EPHX1 | |
| SCHEMBL2738502 | 0.79 | ALDH1A1 (0.47) | CTSSEPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135749-A2 | BIOMARKERS FOR PREDICTING SENSITIVITY TO CANCER TREATMENTS | GENENTECH, INC. (US) | 2012-10-04 | — | — | WO | disclosed |
| WO-2012087336-A1 | AUTOPHAGY INDUCER AND INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NEOPLASMS | GENENTECH, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2011130654-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | GENENTECH, INC. (US) | 2011-10-20 | — | — | WO | disclosed |