Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738606 | 1.00 | ALDH1A1 (0.47) | ALDH1A1HPGDHSD17B10NTSR1POLB | |
| SCHEMBL8223521 | 0.87 | MEN1 (0.53) | ALDH1A1NTSR1POLBADRA1AADRB2 | |
| SCHEMBL2739199 | 0.87 | MEN1 (0.53) | ALDH1A1NTSR1POLBADRA1AADRB2 | |
| SCHEMBL684688 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HPGDHSD17B10NTSR1POLB | |
| SCHEMBL684992 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HPGDHSD17B10NTSR1POLB | |
| SCHEMBL12028860 | 0.86 | ALDH1A1 (0.42) | ALDH1A1POLBHTR2ACHRM2MEN1 | |
| SCHEMBL2739137 | 0.85 | NTSR1 (0.56) | ALDH1A1NTSR1POLBADRA1AADRB2 | |
| SCHEMBL2738589 | 0.85 | NTSR1 (0.56) | ALDH1A1NTSR1POLBADRA1AADRB2 | |
| SCHEMBL8223281 | 0.85 | NTSR1 (0.56) | ALDH1A1NTSR1POLBADRA1AADRB2 | |
| SCHEMBL2738767 | 0.85 | NTSR1 (0.59) | ALDH1A1NTSR1POLBADRA1AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2402325-B1 | Hydroxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |