Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567511 | 0.85 | IMPDH2 (0.33) | SMN1; SMN2KDM4EKMT2AMEN1CYP2C9 | |
| SCHEMBL27386126 | 0.84 | NPC1 (0.37) | TSHRMAPK1SMN1; SMN2CNR2KDM4E | |
| SCHEMBL8593844 | 0.81 | TSHR (0.46) | TSHRMAPK1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL27367262 | 0.80 | TSHR (0.49) | TSHRMAPK1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL23169065 | 0.80 | TSHR (0.53) | TSHRMAPK1SMN1; SMN2CNR2KDM4E | |
| SCHEMBL9766076 | 0.79 | TSHR (0.52) | TSHRMAPK1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL13753996 | 0.77 | PTGS2 (0.34) | IMPDH2 | |
| SCHEMBL27387387 | 0.77 | PTPN1 (0.44) | TSHRMAPK1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL27388705 | 0.77 | MEN1 (0.41) | TSHRMAPK1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL9766080 | 0.76 | TSHR (0.44) | TSHRMAPK1SMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064955-C | Fluorine-containing benzoylguanidines | MERCK PATENT GMBH (DE) | 2001-04-25 | — | — | CN | disclosed |
| CN-1143632-A | Fluorine-containing benzoylguanidines | MERCK PATENT GMBH (DE) | 1997-02-26 | — | — | CN | disclosed |