Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 14/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.64 |
| ▸ | HTR3A | P46098 | 5/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.63 |
| ▸ | HTR3B | O95264 | 2/20 | 0.63 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.63 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.63 |
| ▸ | HTR5A | P47898 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739063 | 0.92 | HTR4 (0.64) | HTR4KCNH2HTR3AHTR3EHTR3B | |
| SCHEMBL2739064 | 0.91 | HTR4 (0.65) | HTR4KCNH2HTR3AHTR3EHTR3B | |
| SCHEMBL2760319 | 0.89 | HTR4 (0.53) | HTR4KCNH2HTR3AHTR3EHTR3B | |
| SCHEMBL218594 | 0.88 | HTR4 (0.64) | HTR4KCNH2HTR3A | |
| SCHEMBL2739065 | 0.88 | HTR4 (0.61) | HTR4KCNH2HTR3AHTR3EHTR3B | |
| SCHEMBL218595 | 0.86 | HTR4 (0.60) | HTR4KCNH2 | |
| SCHEMBL6839835 | 0.85 | HTR4 (0.70) | HTR4KCNH2HTR3A | |
| SCHEMBL28920790 | 0.85 | HTR4 (0.70) | HTR4KCNH2HTR3A | |
| SCHEMBL9179234 | 0.84 | HTR4 (0.67) | HTR4KCNH2HTR3AHTR3EHTR3B | |
| SCHEMBL8054851 | 0.84 | HTR4 (0.77) | HTR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |