Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 2/20 | 1.00 |
| ▸ | PRKCG | P05129 | 2/20 | 1.00 |
| ▸ | PRKCB | P05771 | 2/20 | 1.00 |
| ▸ | PRKCA | P17252 | 2/20 | 1.00 |
| ▸ | PRKCH | P24723 | 2/20 | 1.00 |
| ▸ | PRKCI | P41743 | 2/20 | 1.00 |
| ▸ | PRKCE | Q02156 | 2/20 | 1.00 |
| ▸ | PRKCQ | Q04759 | 2/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 2/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 2/20 | 1.00 |
| ▸ | PRKD1 | Q15139 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 11/20 | 0.61 |
| ▸ | GABRP | O00591 | 4/20 | 0.61 |
| ▸ | GABRD | O14764 | 4/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739491 | 1.00 | PRKD3 (1.00) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739506 | 0.94 | PRKD3 (0.89) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739509 | 0.92 | PRKD3 (0.85) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739508 | 0.92 | PRKD3 (1.00) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739504 | 0.87 | PRKD3 (0.76) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739500 | 0.86 | PRKD3 (0.76) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739501 | 0.85 | PRKD3 (0.74) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL14658843 | 0.83 | PRKD3 (0.71) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739447 | 0.82 | PRKD3 (0.69) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2739452 | 0.82 | PRKD3 (0.69) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278305-B2 | Myosin light chain kinase inhibitor compounds, compositions and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | claimed |
| US-20100240668-A1 | Myosin Light Chain Kinase Inhibitor Compounds, Compositions and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-23 | — | — | US | claimed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-7888357-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888357-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2011-02-15 | — | — | US | disclosed |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240668-A1 | Myosin Light Chain Kinase Inhibitor Compounds, Compositions and Related Methods of Use | MYLK, MYLK2, MYLK3 | PRKD3 238/4885PRKCG 31/4885PRKCB 26/4885 |
| US-20100317665-A1 | Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death | CASP2, CASP1, DAPK2 | PRKD3 293/4885PRKCG 151/4885PRKCB 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.