Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLM | Q9NP87 | 2/20 | 0.44 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.44 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.44 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371722 | 0.77 | POLM (0.57) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL27370235 | 0.76 | POLM (0.60) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL27584372 | 0.74 | ELANE (0.57) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL8675067 | 0.72 | KMT2A (0.45) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL9312497 | 0.72 | KMT2A (0.59) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL7443903 | 0.71 | KMT2A (0.51) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL22141048 | 0.71 | KMT2A (0.50) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL27399005 | 0.70 | ALDH1A1 (0.42) | KMT2AMEN1KDM4EPKMPTPN1 | |
| SCHEMBL27393368 | 0.69 | MAPT (0.38) | KMT2AMEN1KDM4EPKMLMNA | |
| SCHEMBL2390126 | 0.69 | KDM4E (0.53) | POLMPOLKPOLLPOLHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |