Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27369444 | 0.78 | MALT1 (0.40) | ALDH1A1GAAMAPTKMT2AKDM4E | |
| SCHEMBL27370234 | 0.76 | ALDH1A1 (0.45) | ALDH1A1GAAMAPTHTTHSD17B10 | |
| SCHEMBL27393368 | 0.75 | MAPT (0.38) | ALDH1A1GAAMAPTHTTHSD17B10 | |
| SCHEMBL11820694 | 0.73 | MEN1 (0.46) | ALDH1A1GAAMAPTHTTHSD17B10 | |
| SCHEMBL6212971 | 0.72 | NLRP3 (0.48) | ALDH1A1GAAMAPTHTTHSD17B10 | |
| SCHEMBL2420372 | 0.72 | PKM (0.47) | ALDH1A1GAAMAPTHSD17B10PKM | |
| SCHEMBL68340 | 0.72 | PKM (0.60) | ALDH1A1HSD17B10PKMNLRP3CYP4F2 | |
| SCHEMBL852520 | 0.71 | PKM (0.53) | ALDH1A1HSD17B10PKMNLRP3CYP4F2 | |
| SCHEMBL29511550 | 0.71 | PKM (0.53) | ALDH1A1HSD17B10PKMNLRP3CYP4F2 | |
| SCHEMBL23218990 | 0.71 | PKM (0.46) | ALDH1A1GAAPKMNLRP3CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |