SCHEMBL27399151

SCHEMBL27399151

Fc1ccc(-c2cncnc2-c2ccc3nccn3c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 13/20 0.51
DYRK1A Q13627 2/20 0.49
AKT1 P31749 1/20 0.45
PIK3CA P42336 1/20 0.45
MTOR P42345 1/20 0.45
MET P08581 1/20 0.40
MAPK9 P45984 1/20 0.39
MAPK10 P53779 1/20 0.39
CYP1A2 P05177 1/20 0.39
METAP2 P50579 1/20 0.39
JAK2 O60674 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27399209 0.80 TGFBR1 (0.60) TGFBR1DYRK1AAKT1PIK3CAMTOR
SCHEMBL1830448 0.78 DYRK1A (0.71) TGFBR1DYRK1AAKT1PIK3CAMTOR
SCHEMBL27399205 0.77 TGFBR1 (0.49) TGFBR1DYRK1AAKT1PIK3CAMTOR
SCHEMBL31051251 0.77 TGFBR1 (0.49) TGFBR1DYRK1AAKT1PIK3CAMTOR
SCHEMBL15639144 0.77 TGFBR1 (0.60) TGFBR1DYRK1AAKT1PIK3CAMTOR
SCHEMBL27399170 0.75 TGFBR1 (0.43) TGFBR1CYP1A2
SCHEMBL31051181 0.75 TGFBR1 (0.41) TGFBR1MAPK9MAPK10
SCHEMBL27399173 0.75 TGFBR1 (0.41) TGFBR1MAPK9MAPK10
SCHEMBL7210230 0.75 MAPK9 (0.59) MAPK9MAPK10
Hydrochloric Acid SCHEMBL27503714 0.74 MAPK9 (0.57) MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024126404-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-06-20 WO disclosed