Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 10/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | TXK | P42681 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.33 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.33 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27399357 | 1.00 | TEAD1 (0.34) | TEAD1EGFRJAK3BTKTXK | |
| SCHEMBL30835965 | 0.80 | USP30 (0.37) | — | |
| SCHEMBL27401246 | 0.76 | TEAD1 (0.42) | TEAD1EGFRBTKKRAS | |
| SCHEMBL30835888 | 0.76 | TEAD1 (0.42) | TEAD1EGFRBTKKRAS | |
| SCHEMBL27399148 | 0.72 | TEAD1 (0.47) | TEAD1KRAS | |
| SCHEMBL27399145 | 0.70 | TEAD1 (0.36) | TEAD1EGFRBTKKRAS | |
| SCHEMBL27399494 | 0.70 | TEAD1 (0.36) | TEAD1EGFRBTKKRAS | |
| SCHEMBL30836081 | 0.68 | TEAD1 (0.54) | TEAD1EGFRBTKKRAS | |
| SCHEMBL27399363 | 0.68 | TEAD1 (0.54) | TEAD1EGFRBTKKRAS | |
| SCHEMBL30835914 | 0.68 | BTK (0.40) | TEAD1JAK3BTKKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4587424-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | Bridgene Biosciences, Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| CN-119894866-A | YAP/TAZ-TEAD oncoprotein inhibitors | 布里奇恩生物科学公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2024059317-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | BRIDGENE BIOSCIENCES, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2024059317-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | BRIDGENE BIOSCIENCES, INC. (US) | 2024-03-21 | — | — | WO | disclosed |