Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 10/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | KRAS | P01116 | 4/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30835888 | 1.00 | TEAD1 (0.42) | TEAD1EGFRKRASBTKHRH3 | |
| SCHEMBL27399356 | 0.88 | KDM4E (0.33) | TEAD1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL27399148 | 0.82 | TEAD1 (0.47) | TEAD1KRASHRH3 | |
| SCHEMBL30835927 | 0.80 | RORC (0.43) | HRH3HPGDSMN1; SMN2 | |
| SCHEMBL27401285 | 0.80 | RORC (0.43) | HRH3HPGDSMN1; SMN2 | |
| SCHEMBL27400930 | 0.77 | TEAD1 (0.45) | TEAD1EGFRKRASBTKERBB2 | |
| SCHEMBL27399360 | 0.76 | TEAD1 (0.34) | TEAD1EGFRKRASBTK | |
| SCHEMBL27399357 | 0.76 | TEAD1 (0.34) | TEAD1EGFRKRASBTK | |
| SCHEMBL30836081 | 0.76 | TEAD1 (0.54) | TEAD1EGFRKRASBTKHPGD | |
| SCHEMBL27399363 | 0.76 | TEAD1 (0.54) | TEAD1EGFRKRASBTKHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059317-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | BRIDGENE BIOSCIENCES, INC. (US) | 2024-03-21 | — | — | WO | disclosed |