Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30905510 | 1.00 | PKMYT1 (0.40) | PKMYT1BRD4TDP2PRMT5LMNA | |
| SCHEMBL27401362 | 0.88 | PKMYT1 (0.44) | PKMYT1PRMT5LMNATHRBPOLB | |
| SCHEMBL30905556 | 0.88 | TDP2 (0.39) | PKMYT1BRD4TDP2THRBADORA2A | |
| SCHEMBL27401713 | 0.84 | KMT2A (0.46) | PKMYT1LMNATHRBTP53POLB | |
| SCHEMBL30905584 | 0.84 | KMT2A (0.46) | PKMYT1LMNATHRBTP53POLB | |
| SCHEMBL27401200 | 0.78 | BRD4 (0.45) | BRD4TDP2PRMT5LMNATP53 | |
| SCHEMBL30905515 | 0.78 | BRD4 (0.45) | BRD4TDP2PRMT5LMNATP53 | |
| SCHEMBL31437247 | 0.76 | TDP2 (0.40) | BRD4TDP2TP53ADORA2AMAPT | |
| SCHEMBL30641218 | 0.76 | TDP2 (0.40) | BRD4TDP2TP53ADORA2AMAPT | |
| SCHEMBL26674505 | 0.76 | TDP2 (0.40) | BRD4TDP2TP53ADORA2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |