SCHEMBL27401613

SCHEMBL27401613

CC(C)Nc1cc(F)c(Cl)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALPL P05186 2/20 0.37
NR4A2 P43354 1/20 0.36
SCN1A P35498 10/20 0.33
SCN5A Q14524 10/20 0.33
SCN8A Q9UQD0 10/20 0.33
BCL6 P41182 1/20 0.33
KDM4E B2RXH2 1/20 0.33
TSHR P16473 1/20 0.33
KAT2B Q92831 1/20 0.33
HTR2A P28223 3/20 0.32
HTR2C P28335 3/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
HTR2B P41595 1/20 0.32
SCN1B Q07699 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27400140 0.76 ALDH1A1 (0.34) ALPLTSHRHTR2AHTR2CHTR2B
SCHEMBL6283513 0.74 NPC1 (0.32)
SCHEMBL25786554 0.73 KMT2A (0.40) NR4A2
SCHEMBL20655526 0.72 NPC1 (0.47) BCL6KDM4ETSHR
SCHEMBL18619482 0.71 NR4A2 (0.36) NR4A2KAT2B
SCHEMBL12368470 0.71 NR4A2 (0.40) NR4A2
SCHEMBL4305366 0.69 CYP3A4 (0.46) NR4A2KDM4ETSHRCYP3A4
SCHEMBL19089429 0.69 RAPGEF4 (0.50) BCL6KDM4ETSHRCYP3A4
SCHEMBL631778 0.69 TSHR (0.53) KDM4ETSHRCYP1A2CYP3A4CYP2C9
SCHEMBL2157691 0.68 CA1 (0.55) NR4A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024123663-A1 ANTIMICROBIAL COMPOUNDS SRI INTERNATIONAL (US) 2024-06-13 WO disclosed