Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 5/20 | 0.76 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.72 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8163316 | 0.99 | CCR5 (0.74) | CCR5USP28USP25HTTLMNA | |
| Hydrochloric Acid SCHEMBL7809179 | 0.99 | CCR5 (0.74) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL5700011 | 0.86 | CCR5 (1.00) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL6183550 | 0.86 | CCR5 (0.73) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL5210786 | 0.84 | CCR5 (0.63) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL3724781 | 0.84 | CCR5 (0.66) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL8160871 | 0.83 | CCR5 (0.69) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL8700626 | 0.83 | USP28 (0.67) | CCR5USP28USP25HTTLMNA | |
| SCHEMBL19001344 | 0.82 | GAA (0.97) | LMNAALDH1A1GAATP53 | |
| SCHEMBL5700091 | 0.82 | CCR5 (0.73) | CCR5USP28USP25HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114598-C | Aromatic compounds and pharmaceutical compositions containing them | ZENECA LTD (GB) | 2003-07-16 | — | — | CN | disclosed |
| CN-1085663-C | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2002-05-29 | — | — | CN | disclosed |
| CN-1286254-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2001-03-07 | — | — | CN | disclosed |
| CN-1193966-A | Aromatic compounds and pharmaceutical compositions containing them | ZENECA LTD (GB) | 1998-09-23 | — | — | CN | disclosed |
| CN-1154106-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 1997-07-09 | — | — | CN | disclosed |