SCHEMBL8700626

SCHEMBL8700626

FC(F)(F)CNCc1cc(Br)ccc1OCc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP28 Q96RU2 2/20 0.67
USP25 Q9UHP3 2/20 0.67
HTT P42858 3/20 0.66
CCR5 P51681 5/20 0.63
ALDH1A1 P00352 3/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
RAB9A P51151 1/20 0.60
LMNA P02545 3/20 0.60
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
NPSR1 Q6W5P4 2/20 0.52
STAT3 P40763 1/20 0.52
CYP1A2 P05177 1/20 0.52
GLA P06280 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
HTR7 P34969 1/20 0.51
HTR6 P50406 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27403102 0.83 CCR5 (0.76) USP28USP25HTTCCR5ALDH1A1
Bromide SCHEMBL8163316 0.82 CCR5 (0.74) USP28USP25HTTCCR5ALDH1A1
Hydrochloric Acid SCHEMBL7809179 0.82 CCR5 (0.74) USP28USP25HTTCCR5ALDH1A1
SCHEMBL6183550 0.80 CCR5 (0.73) USP28USP25HTTCCR5ALDH1A1
SCHEMBL8160871 0.80 CCR5 (0.69) USP28USP25HTTCCR5ALDH1A1
SCHEMBL31252520 0.79 ALDH1A1 (0.98) USP28USP25HTTCCR5ALDH1A1
SCHEMBL5700091 0.79 CCR5 (0.73) USP28USP25HTTCCR5ALDH1A1
SCHEMBL31065381 0.78 CCR5 (0.62) USP28USP25HTTCCR5ALDH1A1
SCHEMBL22786894 0.77 USP28 (0.64) USP28USP25HTTCCR5ALDH1A1
SCHEMBL15196646 0.76 CCR5 (0.63) USP28USP25HTTCCR5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5843942-A Aromatic amino ethers as pain relieving agents ZENECA LIMITED (GB) 1998-12-01 US disclosed
WO-1996003380-A1 AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS ZENECA LIMITED (GB) 1996-02-08 WO disclosed