Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | ACLY | P53396 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740978 | 0.90 | ACLY (0.50) | KDM4ESMN1; SMN2TSHRFABP4ACLY | |
| SCHEMBL2740977 | 0.78 | KLK7 (0.48) | KDM4ESMN1; SMN2ALDH1A1LMNAKLK7 | |
| SCHEMBL14389382 | 0.77 | KDM4E (0.70) | KDM4ESMN1; SMN2TSHRACLYALDH1A1 | |
| SCHEMBL16119560 | 0.76 | CYP2C9 (0.76) | KDM4ESMN1; SMN2TSHRALDH1A1LMNA | |
| SCHEMBL29535237 | 0.76 | CYP2C9 (0.76) | KDM4ESMN1; SMN2TSHRALDH1A1LMNA | |
| SCHEMBL14160377 | 0.76 | ACLY (0.50) | KDM4ESMN1; SMN2TSHRFABP4ACLY | |
| SCHEMBL7573034 | 0.76 | ACLY (0.53) | KDM4ESMN1; SMN2TSHRACLYALDH1A1 | |
| SCHEMBL2740996 | 0.75 | PTGES2 (0.56) | KDM4ESMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL2740981 | 0.74 | PTGES2 (0.58) | KDM4ETSHRALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2740982 | 0.73 | SLC22A12 (0.68) | ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | THE GENETICS COMPANY, INC. (CH) | 2010-09-30 | — | — | US | disclosed |
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | THE GENETICS COMPANY, INC. (CH) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | BCOR, CBR3, SULT1E1 | KDM4E 229/4885SMN1; SMN2 2187/4885TSHR 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.