Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.47 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572428 | 0.90 | ALDH1A1 (0.54) | SLC40A1HSD11B1ALDH1A1MAPTTSHR | |
| SCHEMBL3873411 | 0.81 | PFKFB3 (0.48) | CYP2C9PFKFB3PFKFB4HSD11B1ALDH1A1 | |
| SCHEMBL7588152 | 0.79 | SLC40A1 (0.59) | SLC40A1HSD11B1ALDH1A1MAPTTSHR | |
| SCHEMBL7594250 | 0.78 | SLC40A1 (0.66) | SLC40A1HSD11B1ALDH1A1CCR4EDNRB | |
| SCHEMBL7594652 | 0.78 | SLC40A1 (0.53) | ACLYSLC40A1HSD11B1EDNRBEDNRA | |
| SCHEMBL12406979 | 0.77 | KDM4E (0.60) | ACLYCYP2C9SLC40A1PFKFB3PFKFB4 | |
| SCHEMBL3873274 | 0.76 | FABP4 (0.49) | PFKFB3PFKFB4ALDH1A1MAPTTP53 | |
| SCHEMBL7578810 | 0.76 | SLC40A1 (0.64) | SLC40A1HSD11B1CCR4EDNRBEDNRA | |
| SCHEMBL7591197 | 0.76 | PTGES2 (0.59) | ACLYSLC40A1HSD11B1CCR4EDNRB | |
| SCHEMBL2174600 | 0.76 | FFAR4 (0.61) | CYP2C9ALDH1A1MAPTTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |