Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 5/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL28091043 | 0.97 | LMNA (0.73) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL27661128 | 0.94 | LMNA (0.69) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Glutarate SCHEMBL27542711 | 0.90 | SLC22A6 (0.73) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL28114194 | 0.88 | GPR84 (0.62) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL105757 | 0.87 | LMNA (0.92) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL465500 | 0.87 | LMNA (0.92) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL28234980 | 0.87 | LMNA (0.92) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Formic Acid SCHEMBL5931486 | 0.86 | GPR84 (0.75) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Adipic Acid SCHEMBL28187590 | 0.86 | LMNA (0.58) | LMNATSHRNFKB1PMP22SLC22A6 | |
| Hexanoate SCHEMBL15260773 | 0.84 | AKR1B1 (0.80) | LMNATSHRSLC22A6GPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167946-A | Sulfonamide compounds with TNAP inhibitory activity | 第一三共株式会社 | 2019-08-23 | — | — | CN | disclosed |
| CN-1098843-C | Isoxazoles | SANKYO CO (JP) | 2003-01-15 | — | — | CN | disclosed |
| CN-1093861-C | 1-methylcarbapenem derivatives | SANKYO CO (JP) | 2002-11-06 | — | — | CN | disclosed |