Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 11/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL227592 | 0.85 | LTA4H (0.54) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL228460 | 0.82 | PSMB1 (0.56) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL228974 | 0.81 | LTA4H (0.54) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL229242 | 0.80 | MCHR1 (0.47) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL226459 | 0.80 | MCHR1 (0.47) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL224755 | 0.79 | MCHR1 (0.47) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL225919 | 0.78 | PSMB1 (0.67) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL8599886 | 0.75 | ESR1 (0.65) | PSMB1PSMB5PSMB2ESR1ESR2 | |
| SCHEMBL6423701 | 0.75 | LTA4H (0.46) | ESR1ESR2LTA4HHRH3 | |
| SCHEMBL227845 | 0.75 | ESR1 (0.45) | ESR1ESR2LTA4HKDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | ESR1, GPER1, ESR2 | PSMB1 658/4885PSMB5 695/4885PSMB2 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.