Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | ECE1 | P42892 | 1/20 | 0.50 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27341574 | 0.95 | REN (0.62) | RENOPRK1LTA4HGHSR | |
| SCHEMBL9875941 | 0.88 | MME (0.59) | RENMMEECE1 | |
| SCHEMBL29971719 | 0.88 | REN (0.60) | RENLTA4HMMEECE1 | |
| SCHEMBL28133942 | 0.88 | REN (0.60) | RENLTA4HMMEECE1 | |
| Triletide SCHEMBL29387766 | 0.87 | REN (0.68) | RENMMEECE1 | |
| Triletide SCHEMBL29403076 | 0.87 | REN (0.68) | RENMMEECE1 | |
| Triletide SCHEMBL27342203 | 0.87 | REN (0.68) | RENMMEECE1 | |
| SCHEMBL27342814 | 0.86 | REN (0.56) | RENMMEECE1 | |
| SCHEMBL13563453 | 0.84 | REN (0.72) | RENGHSR | |
| Bromide SCHEMBL11571243 | 0.84 | OPRK1 (0.67) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043133-A | imidazole-containing peptide and preparation method thereof | TANABE SEIYAKU CO (JP) | 1990-06-20 | — | — | CN | disclosed |