Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15165804 | 0.75 | TP53 (0.50) | KDM4ESMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL27423842 | 0.75 | KDM4E (0.46) | KDM4ESMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30974271 | 0.75 | KDM4E (0.46) | KDM4ESMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL20921174 | 0.73 | KDM4E (0.50) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3962704 | 0.71 | KDM4E (0.48) | KDM4ESMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL31031663 | 0.71 | MAPT (0.53) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3967968 | 0.71 | MEN1 (0.44) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL28308116 | 0.70 | GAA (1.00) | KDM4ESMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30103304 | 0.70 | KDM4E (0.58) | KDM4ESMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30102471 | 0.70 | KDM4E (0.58) | KDM4ESMN1; SMN2NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024129780-A1 | BENZIMIDAZOLE DERIVATIVES AS GPX4 INHIBITORS | SONATA THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |