Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27423842 | 1.00 | KDM4E (0.46) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27423835 | 0.87 | KDM4E (0.50) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13291552 | 0.79 | KDM4E (0.45) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30974230 | 0.79 | KDM4E (0.39) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30974281 | 0.77 | MEN1 (0.46) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27423824 | 0.77 | MEN1 (0.46) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL948951 | 0.75 | HTR6 (0.47) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27423871 | 0.75 | KDM4E (0.56) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL20983873 | 0.72 | HTR3A (0.48) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL383293 | 0.71 | TMEM97 (0.62) | GPR119ALDH1A1LMNAMAPTPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024129780-A1 | BENZIMIDAZOLE DERIVATIVES AS GPX4 INHIBITORS | SONATA THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |