Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 12/20 | 0.71 |
| ▸ | ACE | P12821 | 2/20 | 0.67 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | MMP2 | P08253 | 2/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30050876 | 0.87 | ECE1 (0.57) | ECE1ACEERAP2MMP1 | |
| SCHEMBL9822631 | 0.85 | ECE1 (0.70) | ECE1ACEERAP2MMP2MMP9 | |
| SCHEMBL4959992 | 0.85 | ERAP2 (0.75) | ECE1ACEERAP2 | |
| SCHEMBL30051190 | 0.85 | ECE1 (0.74) | ECE1ACEERAP2ALOX15MMP2 | |
| SCHEMBL4959976 | 0.85 | ERAP2 (0.75) | ECE1ACEERAP2 | |
| SCHEMBL30051783 | 0.85 | ECE1 (0.70) | ECE1ACEERAP2MMP2MMP9 | |
| SCHEMBL21411572 | 0.85 | ECE1 (0.73) | ECE1ACEERAP2ALOX15MMP2 | |
| SCHEMBL21411574 | 0.85 | ECE1 (0.73) | ECE1ACEERAP2ALOX15MMP2 | |
| SCHEMBL9027402 | 0.85 | ECE1 (0.77) | ECE1ACEERAP2ALOX15MMP2 | |
| SCHEMBL120495 | 0.84 | ALOX15 (0.67) | ECE1ACEALOX15MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1105573-C | Pharmaceutical combination | HOFFMANN LA ROCHE (CH) | 2003-04-16 | — | — | CN | disclosed |
| CN-1107364-A | Pharmaceutical combination | HOFFMANN LA ROCHE (CH) | 1995-08-30 | — | — | CN | disclosed |