SCHEMBL120495

SCHEMBL120495

O=CNC(Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.67
ALDH1A1 P00352 1/20 0.65
ACE P12821 3/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
KDM4E B2RXH2 2/20 0.60
MAPT P10636 2/20 0.60
APAF1 O14727 1/20 0.60
POLB P06746 1/20 0.60
RECQL P46063 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
MEN1 O00255 1/20 0.60
LMNA P02545 1/20 0.60
MPO P05164 1/20 0.60
TSHR P16473 1/20 0.60
BLM P54132 1/20 0.60
PMP22 Q01453 1/20 0.60
KMT2A Q03164 1/20 0.60
HIF1A Q16665 1/20 0.60
ITGB2 P05107 3/20 0.60
ICAM1 P05362 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5519036 1.00 ALOX15 (0.67) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
SCHEMBL120493 1.00 ALOX15 (0.67) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
SCHEMBL29402200 1.00 ALOX15 (0.67) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
Bromobenzene SCHEMBL27477821 0.94 FPR2 (0.64) ALOX15ALDH1A1ACESMN1; SMN2ITGB2
Indole SCHEMBL7704076 0.91 ALDH1A1 (0.59) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
Indole SCHEMBL27577896 0.91 ALDH1A1 (0.59) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
SCHEMBL24425711 0.88 ALOX15 (0.62) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
SCHEMBL7326281 0.88 GHSR (0.59) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
SCHEMBL9845636 0.87 GHSR (0.55) ALOX15ALDH1A1ACESMN1; SMN2KDM4E
SCHEMBL30782236 0.86 ALOX15 (0.70) ALOX15ACESMN1; SMN2KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2278992-A2 THERAPY FOR VITILIGO Clinuvel Pharmaceuticals Limited (AU) 2011-02-02 EP claimed
WO-2009118191-A2 THERAPY FOR VITILIGO CLINUVEL PHARMACEUTICALS LIMITED (AU) 2009-10-01 WO claimed
EP-0552417-B1 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-07-07 EP claimed
US-5840692-A ADMINISTERING SPECIFIED PEPTIDE TO MIMIC BIOLOGICAL ACTIVITY OF THROMBOSPONDIN ALLEGHENY UNIVERSITY OF THE HEALTH SCIENCES (US) 1998-11-24 US claimed
EP-0528312-B1 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-07-16 EP claimed
EP-0714909-A1 Composition for prophylaxis or treatment of pulmonary circulatory diseases Takeda Chemical Industries, Ltd. (JP) 1996-06-05 EP claimed
US-5426100-A Therapeutic uses including antitumor agents, anticoagulants and wound healing agents W. R. GRACE & CO.-CONN. (US) 1995-06-20 US claimed
EP-0552417-A1 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-07-28 EP claimed
US-5190918-A Antitumor W. R. GRACE & CO.-CONN. (US) 1993-03-02 US claimed
EP-0528312-A2 Cyclic peptides and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-02-24 EP claimed
EP-0443404-A1 Peptide fragments and analogs of thrombospondin W.R. Grace & Co.-Conn. (US) 1991-08-28 EP claimed
US-4283337-A Process for the purification of tryptophane and derivatives of tryptophane DEUTSCHE GOLD UND- SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1981-08-11 US claimed
WO-2025081231-A1 INHIBITORS AND USES THEREFOR Infensa Bioscience Pty Ltd (AU) 2025-04-24 WO disclosed
US-20240344241-A1 PROTEINACEOUS MOLECULES AND USES THEREFOR THE UNIVERSITY OF TOKYO (JP) 2024-10-17 US disclosed
EP-4416282-A1 PROTEINACEOUS MOLECULES AND USES THEREFOR The University of Queensland (AU) 2024-08-21 EP disclosed
US-20240218018-A1 Compstatin Analogs with Increased Solubility and Improved Pharmacokinetic Properties THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2024-07-04 US disclosed
WO-1987005909-A2 RENIN INHIBITORS HAVING A LACTAM PSEUDO DIPEPTIDE THE UPJOHN COMPANY (US) 1987-10-08 WO disclosed
EP-0220157-A2 Mitogenic peptides WASHINGTON UNIVERSITY (US) 1987-04-29 EP disclosed
US-4507230-A DETACHING RESINS FROM PEPTIDES RESEARCH CORPORATION (US) 1985-03-26 US disclosed
US-4283337-A Process for the purification of tryptophane and derivatives of tryptophane DEUTSCHE GOLD UND- SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1981-08-11 US disclosed