Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27454730 | 0.80 | MTNR1A (0.34) | AAK1MTNR1AMTNR1BALDH1A1POLB | |
| SCHEMBL23888206 | 0.78 | MTNR1A (0.34) | AAK1MTNR1AMTNR1BALDH1A1PKM | |
| SCHEMBL30178314 | 0.78 | MTNR1A (0.34) | AAK1MTNR1AMTNR1BALDH1A1PKM | |
| SCHEMBL22134679 | 0.78 | ALDH1A1 (0.35) | MTNR1AMTNR1BALDH1A1NCEH1PKM | |
| SCHEMBL27457413 | 0.76 | L3MBTL1 (0.42) | ALDH1A1SMN1; SMN2L3MBTL1HTTMEN1 | |
| SCHEMBL31342724 | 0.76 | BRD4 (0.43) | AAK1MTNR1AMTNR1BALDH1A1CYP1A2 | |
| SCHEMBL4014579 | 0.76 | BRD4 (0.43) | AAK1MTNR1AMTNR1BALDH1A1CYP1A2 | |
| SCHEMBL13485114 | 0.74 | HPGD (0.38) | ALDH1A1POLBSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL30755354 | 0.74 | GRM6 (0.42) | MTNR1AMTNR1BALDH1A1POLBCYP1A2 | |
| SCHEMBL27380064 | 0.74 | GRM6 (0.42) | MTNR1AMTNR1BALDH1A1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101370505-B | Treatment of ocular neovascular disorders such as macular degeneration, angioid streaks, uveitis and macular edema | SMITHKLINE BEECHAM CORP | 2012-03-21 | — | — | CN | disclosed |
| CN-101370505-A | Treatment of ocular neovascular disorders such as macular degeneration, angioid streaks, uveitis and macular edema | SMITHKLINE BEECHAM CORP (US) | 2009-02-18 | — | — | CN | disclosed |
| CN-1114403-C | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2003-07-16 | — | — | CN | disclosed |
| CN-1238689-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-12-15 | — | — | CN | disclosed |