Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PRF1 | P14222 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | SDCBP | O00560 | 1/20 | 0.36 |
| ▸ | SDC2 | P34741 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24109490 | 0.87 | HSD17B10 (0.44) | MAP3K5THRBALOX15KDM4EALDH1A1 | |
| SCHEMBL17517151 | 0.79 | MAP3K5 (0.42) | MAP3K5THRBKCNH2LMNA | |
| SCHEMBL18086772 | 0.78 | SDCBP (0.45) | MAP3K5THRBTDP1L3MBTL1SDCBP | |
| SCHEMBL21939317 | 0.78 | ALDH1A1 (0.44) | MAP3K5THRBALOX15KDM4EALDH1A1 | |
| SCHEMBL18086765 | 0.78 | KCNH2 (0.48) | MAP3K5THRBTDP1KCNH2MAPT | |
| SCHEMBL18591660 | 0.78 | SDCBP (0.45) | MAP3K5SDCBPSDC2KCNH2MEN1 | |
| SCHEMBL13322654 | 0.75 | LMNA (0.42) | MAP3K5THRBALOX15KDM4EPRF1 | |
| SCHEMBL14084763 | 0.75 | MEN1 (0.45) | MAP3K5ALOX15KDM4EALDH1A1TDP1 | |
| SCHEMBL13015321 | 0.75 | ALDH1A1 (0.48) | KDM4EALDH1A1L3MBTL1KCNH2MEN1 | |
| SCHEMBL14072400 | 0.75 | NPC1 (0.44) | MAP3K5THRBALOX15ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217972-A1 | GLUTARIMIDE-CONTAINING PAN-KRAS-MUTANT DEGRADER COMPOUNDS AND USES THEREOF | TIGER BIOTHERAPEUTICS INC. | 2024-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217972-A1 | GLUTARIMIDE-CONTAINING PAN-KRAS-MUTANT DEGRADER COMPOUNDS AND USES THEREOF | KRAS, VHL, HRAS | MAP3K5 1940/4885THRB 4099/4885ALOX15 3752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.