SCHEMBL27430769

SCHEMBL27430769

C=CCc1ccc(O)c(-c2cc(CCC)ccc2N=O)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 10/20 0.59
GABRB2 P47870 10/20 0.59
CNR2 P34972 5/20 0.59
CNR1 P21554 4/20 0.59
MEN1 O00255 3/20 0.59
GAA P10253 3/20 0.59
KMT2A Q03164 3/20 0.59
MAPT P10636 2/20 0.59
ALDH1A1 P00352 2/20 0.59
KDM4E B2RXH2 1/20 0.59
ALDH2 P05091 1/20 0.59
AKR1B1 P15121 1/20 0.59
HPGD P15428 1/20 0.59
PPARG P37231 1/20 0.59
PPARD Q03181 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59
TNKS O95271 1/20 0.51
PARP1 P09874 1/20 0.51
ALOX5 P09917 8/20 0.46
POLB P06746 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12698261 0.91 GABRA1 (0.72) GABRA1GABRB2CNR2CNR1MEN1
SCHEMBL20429858 0.89 CNR1 (0.71) GABRA1GABRB2CNR2CNR1MEN1
SCHEMBL7747447 0.88 GABRA1 (0.77) GABRA1GABRB2CNR2CNR1MEN1
SCHEMBL17690483 0.82 GABRA1 (0.53) GABRA1GABRB2CNR2CNR1MEN1
SCHEMBL20429859 0.81 CNR1 (0.57) CNR2CNR1ALDH1A1HPGDNPSR1
Magnolol SCHEMBL5511922 0.79 GABRA1 (0.72) GABRA1GABRB2CNR2CNR1MEN1
Magnolol SCHEMBL23119980 0.77 GABRA1 (0.85) GABRA1GABRB2CNR2CNR1MEN1
Magnolol SCHEMBL29538482 0.77 GABRA1 (1.00) GABRA1GABRB2CNR2CNR1MEN1
Magnolol SCHEMBL132477 0.77 GABRA1 (1.00) GABRA1GABRB2CNR2CNR1MEN1
Magnolol SCHEMBL29649179 0.77 GABRA1 (1.00) GABRA1GABRB2CNR2CNR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024137264-A1 POLYPHENOLIC BORONATES AND USE THEREOF THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) 2024-06-27 WO disclosed