Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434412 | 0.87 | PDE2A (0.44) | MAPTALDH1A1NPSR1POLBHTT | |
| SCHEMBL7683018 | 0.86 | POLB (0.40) | MAPTALDH1A1NPSR1DYRK1APOLB | |
| SCHEMBL27410461 | 0.84 | ACHE (0.41) | MAPTALDH1A1NPSR1POLBHTT | |
| SCHEMBL27435510 | 0.82 | DYRK1A (0.35) | MAPTALDH1A1NPSR1DYRK1APOLB | |
| SCHEMBL27413423 | 0.79 | TLR8 (0.34) | PDE2APDE10AKMT2A | |
| SCHEMBL27541048 | 0.77 | MEN1 (0.33) | PDE2APDE10AKMT2A | |
| SCHEMBL7682502 | 0.75 | PDE2A (0.43) | MAPTALDH1A1NPSR1POLBHTT | |
| SCHEMBL27562188 | 0.72 | CYP19A1 (0.37) | ALDH1A1TP53HTTKMT2AKDM4E | |
| SCHEMBL7682046 | 0.71 | POLB (0.37) | MAPTALDH1A1NPSR1DYRK1APOLB | |
| SCHEMBL7678787 | 0.70 | HPGD (0.34) | MAPTALDH1A1NPSR1DYRK1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1103770-C | Quinoxalinediones | PFIZER RES AND DEV CO N V S A (IE) | 2003-03-26 | — | — | CN | disclosed |
| CN-1213369-A | Quinoxalinedione compound | PFIZER RES & DEV (IE) | 1999-04-07 | — | — | CN | disclosed |