Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434412 | 0.91 | PDE2A (0.44) | HTTALDH1A1LMNAPOLBPDE2A | |
| SCHEMBL7676180 | 0.90 | ACHE (0.40) | ACHEHTTALDH1A1TSHRGAA | |
| SCHEMBL27433674 | 0.84 | MAPT (0.36) | HTTALDH1A1GAAPOLBKDM4E | |
| SCHEMBL27489462 | 0.83 | APLNR (0.41) | HTTALDH1A1TSHRPDE2AAPLNR | |
| SCHEMBL27502563 | 0.82 | APLNR (0.43) | HTTALDH1A1PDE2AAPLNRMAPK1 | |
| SCHEMBL27541050 | 0.81 | APLNR (0.41) | HTTALDH1A1PDE2AAPLNRMAPT | |
| SCHEMBL7682502 | 0.80 | PDE2A (0.43) | HTTALDH1A1TSHRLMNAPOLB | |
| SCHEMBL27409634 | 0.75 | PDE10A (0.37) | HTTALDH1A1GAAKDM4EPDE2A | |
| SCHEMBL27435510 | 0.75 | DYRK1A (0.35) | HTTALDH1A1GAAPOLBKDM4E | |
| SCHEMBL27487153 | 0.72 | GLA (0.37) | ALDH1A1APLNRMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1103770-C | Quinoxalinediones | PFIZER RES AND DEV CO N V S A (IE) | 2003-03-26 | — | — | CN | disclosed |
| CN-1213369-A | Quinoxalinedione compound | PFIZER RES & DEV (IE) | 1999-04-07 | — | — | CN | disclosed |