Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682046 | 0.87 | POLB (0.37) | DYRK1APDE2APDE10AALDH1A1MAPT | |
| SCHEMBL27433674 | 0.82 | MAPT (0.36) | DYRK1ASIRT2SIRT1SIRT3PDE2A | |
| SCHEMBL27413978 | 0.80 | MEN1 (0.31) | PDE10A | |
| SCHEMBL27434412 | 0.78 | PDE2A (0.44) | PDE2APDE10AALDH1A1MAPTNPSR1 | |
| SCHEMBL27410461 | 0.75 | ACHE (0.41) | PDE2AALDH1A1MAPTNPSR1L3MBTL1 | |
| SCHEMBL7683018 | 0.71 | POLB (0.40) | DYRK1APDE2APDE10AALDH1A1MAPT | |
| SCHEMBL27409634 | 0.71 | PDE10A (0.37) | PDE2APDE10AALDH1A1MAPTNPSR1 | |
| SCHEMBL7682502 | 0.69 | PDE2A (0.43) | SIRT2SIRT1PDE2APDE10AALDH1A1 | |
| SCHEMBL27413423 | 0.67 | TLR8 (0.34) | PDE2APDE10A | |
| SCHEMBL7676180 | 0.66 | ACHE (0.40) | PDE2AALDH1A1MAPTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1103770-C | Quinoxalinediones | PFIZER RES AND DEV CO N V S A (IE) | 2003-03-26 | — | — | CN | disclosed |
| CN-1213369-A | Quinoxalinedione compound | PFIZER RES & DEV (IE) | 1999-04-07 | — | — | CN | disclosed |