Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL6544596 | 1.00 | LMNA (0.53) | LMNAALKBH5SUCNR1EGLN1MAPT | |
| Benzidine SCHEMBL28841695 | 0.90 | CYP3A4 (0.52) | LMNAALKBH5SUCNR1EGLN1MAPT | |
| Benzidine SCHEMBL28008037 | 0.90 | CYP3A4 (0.52) | LMNAALKBH5SUCNR1EGLN1MAPT | |
| Succinic Acid SCHEMBL28213289 | 0.89 | TSHR (0.58) | LMNAALKBH5SUCNR1EGLN1MAPT | |
| Adipic Acid SCHEMBL29044502 | 0.89 | LMNA (0.58) | LMNAMAPTHIF1AKDM4ESLC22A6 | |
| SCHEMBL2652443 | 0.86 | NR4A2 (0.65) | LMNAMAPTHIF1AKDM4ESLC22A6 | |
| Hydrochloric Acid SCHEMBL9462713 | 0.84 | NR4A2 (0.63) | LMNAMAPTHIF1AKDM4ESLC22A6 | |
| E388 SCHEMBL11805388 | 0.83 | HSD17B10 (0.64) | LMNAMAPTHIF1AKDM4ESLC22A6 | |
| SCHEMBL73828 | 0.83 | FFAR1 (0.65) | KEAP1MAOA | |
| SCHEMBL5486191 | 0.82 | TDP1 (0.43) | LMNAMAPTHIF1AKDM4ESLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1104503-C | Method for producing optical amino-acid | MITSUISHI RAYON CO LTD (JP) | 2003-04-02 | — | — | CN | disclosed |
| CN-1143114-A | Method for producing optical amino-acid | NIPPON CHEMICAL INDUSTRY CO LT (JP) | 1997-02-19 | — | — | CN | disclosed |