Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27574374 | 0.98 | ALDH1A1 (0.55) | ALDH1A1GAAPDE10AHTTCYP3A4 | |
| Quinoline SCHEMBL27586146 | 0.87 | ALDH1A1 (0.53) | ALDH1A1GAAPDE10AHTTCYP3A4 | |
| Quinoxaline SCHEMBL27913231 | 0.86 | ALDH1A1 (0.41) | ALDH1A1GAASMN1; SMN2NPC1POLB | |
| Quinoline SCHEMBL27788010 | 0.84 | ALDH1A1 (0.50) | ALDH1A1GAAPDE10AHTTCYP3A4 | |
| Quinoxaline SCHEMBL27907726 | 0.84 | ALDH1A1 (0.41) | ALDH1A1GAASMN1; SMN2NPC1POLB | |
| Ethoxycarbonyl Group SCHEMBL27997141 | 0.83 | ALDH1A1 (0.47) | ALDH1A1GAAHTTCYP3A4ALOX15 | |
| Quinoline SCHEMBL28060746 | 0.82 | ALDH1A1 (0.65) | ALDH1A1GAAPDE10AHTTCYP3A4 | |
| Quinoline SCHEMBL6808379 | 0.82 | ALDH1A1 (0.65) | ALDH1A1GAAPDE10AHTTCYP3A4 | |
| Quinoline SCHEMBL1257445 | 0.80 | ALDH1A1 (0.68) | ALDH1A1GAAPDE10AHTTCYP3A4 | |
| Quinoline SCHEMBL28250556 | 0.80 | ALDH1A1 (0.74) | ALDH1A1PDE10AHTTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115825057-B | Application of quinoline carboxylic ester organic heterocyclic small molecule | 郑州轻工业大学 | 2023-08-22 | — | — | CN | claimed |
| CN-115825057-A | Application of quinoline carboxylic ester organic heterocyclic micromolecules | 郑州轻工业大学 | 2023-03-21 | — | — | CN | claimed |
| CN-1886124-A | Method for inhibiting production of remnant lipoproteins | JAPAN TOBACCO INC (JP) | 2006-12-27 | — | — | CN | claimed |
| CN-1635911-A | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors | PFIZER PROD INC (US) | 2005-07-06 | — | — | CN | claimed |
| CN-119019327-A | Acetylation method of quinoline or isoquinoline compounds | 常州工程职业技术学院 | 2024-11-26 | — | — | CN | disclosed |
| CN-119019327-A | Acetylation method of quinoline or isoquinoline compounds | 常州工程职业技术学院 | 2024-11-26 | — | — | CN | disclosed |
| CN-115825057-B | Application of quinoline carboxylic ester organic heterocyclic small molecule | 郑州轻工业大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-115825057-A | Application of quinoline carboxylic ester organic heterocyclic micromolecules | 郑州轻工业大学 | 2023-03-21 | — | — | CN | disclosed |
| CN-110003121-A | A kind of 3,4- dihydroquinazoline derivatives and preparation method thereof, application | 郑州大学 | 2019-07-12 | — | — | CN | disclosed |
| CN-109762768-A | Bacillus B8W22 and its application | 浙江工业大学 | 2019-05-17 | — | — | CN | disclosed |
| CN-109689639-A | Spirolactams as ROCK inhibitor | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-108484497-A | A kind of synthetic method of 3- amino -7- chloroquinolines | 苏州康润医药有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-1665536-A | Use of CETP inhibitors and antihypertensive agents as well as optionally HMG COA reductase inhibitors | PFIZER PROD INC (US) | 2005-09-07 | — | — | CN | disclosed |
| CN-1635911-A | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors | PFIZER PROD INC (US) | 2005-07-06 | — | — | CN | disclosed |
| CN-1523979-A | Pharmaceutical compositions of adsorbates of amorphous drug | �Ʒ� | 2004-08-25 | — | — | CN | disclosed |
| CN-1515259-A | 4-aminosubstituted-2-substituted-1,2,3,4-tetrahydroquinoline used as CETP inhibitor | �������Զ�˹�Ʒ� | 2004-07-28 | — | — | CN | disclosed |
| CN-1128790-C | 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents | UPJOHN CO (US) | 2003-11-26 | — | — | CN | disclosed |
| CN-1318058-A | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines as CRTP inhibitors | PFIZER PROD INC (US) | 2001-10-17 | — | — | CN | disclosed |
| CN-1318057-A | 4-amino substituted-2-substituted-1, 2,3, 4-tetrahydroquinolines as CETP inhibitors | PFIZER PROD INC (US) | 2001-10-17 | — | — | CN | disclosed |
| CN-1281439-A | 4-hydroxyquinoline-3-carboxamide and hydrazide compounds as antiviral agents | UPJOHN CO (US) | 2001-01-24 | — | — | CN | disclosed |