⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27077756 | 0.90 | NPC1 (0.31) | — | |
| SCHEMBL27077669 | 0.83 | KDM4E (0.33) | — | |
| SCHEMBL27077732 | 0.81 | NPC1 (0.33) | — | |
| SCHEMBL27435356 | 0.81 | NPC1 (0.32) | — | |
| SCHEMBL29987343 | 0.80 | NPC1 (0.34) | — | |
| SCHEMBL27435380 | 0.78 | NPC1 (0.34) | — | |
| SCHEMBL27077783 | 0.77 | F2RL1 (0.32) | — | |
| SCHEMBL27077653 | 0.76 | NPC1 (0.31) | — | |
| SCHEMBL29987559 | 0.74 | DGAT1 (0.32) | — | |
| SCHEMBL27077755 | 0.72 | NPC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-07-04 | — | — | US | disclosed |
| US-20240217968-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-07-04 | — | — | US | disclosed |
| EP-4313300-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022207752-A1 | PHARMACEUTICAL COMPOUND | Duke Street Bio Limited (GB) | 2022-10-06 | — | — | WO | disclosed |