Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743552 | 0.83 | KDM4E (0.57) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL5534604 | 0.80 | PDE4A (0.52) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL26768678 | 0.80 | BAZ2B (0.56) | PDE4APDE4BPDE4CPDE4DBAZ2B | |
| SCHEMBL487944 | 0.75 | HSD17B10 (0.62) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL28043292 | 0.74 | PDE5A (0.47) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL2743793 | 0.74 | CYP3A4 (0.44) | — | |
| SCHEMBL643649 | 0.73 | CYP1A2 (0.62) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL31134292 | 0.73 | PDE4B (0.47) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL28312125 | 0.73 | PDE4A (0.52) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL11928777 | 0.72 | PDE4A (0.44) | PDE5APDE4APDE1APDE1BPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178578-B2 | Chemical compounds | THE UNIVERSITY OF MANCHESTER (GB) | 2012-05-15 | — | — | US | disclosed |
| US-20100016261-A1 | CHEMICAL COMPOUNDS | THE UNIVERSITY OF MANCHESTER (GB) | 2010-01-21 | — | — | US | disclosed |
| EP-2101755-A2 | POLYALKYLOXYDIBENZ (C,E) OXEPINE DERIVATIVES AS MEDICAMENTS | The University of Manchester (GB) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008075048-A2 | POLYALKYLOXYDIBENZ ( C, E) OXEPINE DERIVATIVES AS MEDICAMENTS | THE UNIVERSITY OF MANCHESTER (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016261-A1 | CHEMICAL COMPOUNDS | CYP11B2, MPO, PIGO | PDE5A 532/4885PDE4A 1791/4885PDE1A 4696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.