Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.36 |
| ▸ | PDE4A | P27815 | 8/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279473 | 1.00 | PDE4D (0.36) | PDE4DPDE4BPDE4APDE4CPTGDR2 | |
| SCHEMBL274953 | 0.99 | PTGDR2 (0.36) | PDE4DPDE4BPDE4APDE4CPTGDR2 | |
| SCHEMBL279471 | 0.99 | PTGDR2 (0.36) | PDE4DPDE4BPDE4APDE4CPTGDR2 | |
| SCHEMBL276376 | 0.91 | SYK (0.39) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL279161 | 0.91 | SYK (0.39) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL275957 | 0.90 | FPR2 (0.34) | — | |
| SCHEMBL278963 | 0.90 | FPR2 (0.34) | — | |
| SCHEMBL279490 | 0.85 | HPGD (0.36) | PDE4DPDE4BPDE4APDE4CPTGDR2 | |
| SCHEMBL274631 | 0.85 | HPGD (0.36) | PDE4DPDE4BPDE4APDE4CPTGDR2 | |
| SCHEMBL276159 | 0.85 | PDE4D (0.35) | PDE4DPDE4BPDE4APDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |
| EP-2229396-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077357-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156610-A1 | Spiroindolinone Derivatives | SDHA, AR, XPOT | PDE4D 2759/4885PDE4B 3594/4885PDE4A 3090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.