Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27442491 | 0.87 | EGFR (0.68) | EGFRFBP1KDM4EAURKBERBB2 | |
| SCHEMBL27544914 | 0.87 | EGFR (0.62) | EGFRKDM4EAURKBERBB2ERBB4 | |
| Hydrochloric Acid SCHEMBL28040048 | 0.79 | AURKB (0.58) | EGFRFBP1KDM4EAURKBERBB2 | |
| SCHEMBL27906493 | 0.79 | EGFR (0.55) | EGFRFBP1KDM4EAURKBABCG2 | |
| SCHEMBL28109591 | 0.78 | EGFR (0.66) | EGFRKDM4EABCG2RAB9A | |
| SCHEMBL27906513 | 0.78 | EGFR (0.54) | EGFRFBP1KDM4EAURKB | |
| SCHEMBL29608178 | 0.76 | EGFR (1.00) | EGFRFBP1KDM4EERBB2ABCG2 | |
| SCHEMBL7221302 | 0.76 | EGFR (1.00) | EGFRFBP1KDM4EERBB2ABCG2 | |
| SCHEMBL28006374 | 0.73 | PDGFRB (0.50) | EGFRKDM4EERBB2ABCG2NPC1 | |
| SCHEMBL28198357 | 0.69 | KDR (0.64) | EGFRAURKBAURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1137100-C | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | ��ʲ | 2004-02-04 | — | — | CN | disclosed |
| CN-1139430-A | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | WARNER LAMBERT CO (US) | 1997-01-01 | — | — | CN | disclosed |