Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.68 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27906493 | 0.89 | EGFR (0.55) | EGFRFBP1MAPTAURKBKDM4E | |
| SCHEMBL27906513 | 0.88 | EGFR (0.54) | EGFRFBP1MAPTAURKBKDM4E | |
| SCHEMBL27441184 | 0.87 | EGFR (0.60) | EGFRFBP1AURKBAURKAPDGFRB | |
| SCHEMBL28109591 | 0.82 | EGFR (0.66) | EGFRMAPTKDM4E | |
| SCHEMBL7222247 | 0.81 | EGFR (1.00) | EGFRFBP1ERBB2 | |
| SCHEMBL27544914 | 0.79 | EGFR (0.62) | EGFRAURKBPDGFRBKDM4EERBB2 | |
| Hydrochloric Acid SCHEMBL28040048 | 0.72 | AURKB (0.58) | EGFRFBP1MAPTAURKBAURKA | |
| SCHEMBL7216285 | 0.70 | EGFR (1.00) | EGFRFBP1ERBB2 | |
| SCHEMBL1418279 | 0.68 | EGFR (0.77) | EGFRFBP1 | |
| SCHEMBL20127275 | 0.68 | EGFR (0.72) | EGFRFBP1MAPTAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1137100-C | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | ��ʲ | 2004-02-04 | — | — | CN | disclosed |
| CN-1139430-A | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | WARNER LAMBERT CO (US) | 1997-01-01 | — | — | CN | disclosed |