Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 3/20 | 0.30 |
| ▸ | BIRC3 | Q13489 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743892 | 0.89 | KLK5 (0.34) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL2744138 | 0.89 | DPP8 (0.41) | DPP8DPP4DPP9DPP7CYP19A1 | |
| SCHEMBL8227246 | 0.81 | ABHD6 (0.38) | DPP8DPP4DPP9DPP7CYP19A1 | |
| SCHEMBL2744148 | 0.81 | — | — | |
| SCHEMBL16418965 | 0.81 | ABHD6 (0.34) | DPP8DPP9DPP7CYP19A1 | |
| Hydrochloric Acid SCHEMBL2743704 | 0.79 | DPP8 (0.47) | DPP8DPP4DPP9DPP7 | |
| SCHEMBL8060885 | 0.79 | XIAP (0.36) | DPP8DPP4DPP9DPP7CYP19A1 | |
| SCHEMBL4406308 | 0.79 | DPP4 (0.44) | DPP8DPP4DPP9DPP7 | |
| SCHEMBL4257147 | 0.79 | DPP4 (0.44) | DPP8DPP4DPP9DPP7 | |
| SCHEMBL2743903 | 0.79 | DPP8 (0.37) | DPP8DPP4DPP9DPP7XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027144-B1 | MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | MSD ITALIA SRL (IT) | 2015-04-29 | — | — | EP | disclosed |
| US-8178520-B2 | Macrocyclic compounds as antiviral agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2012-05-15 | — | — | US | disclosed |
| US-20090258891-A1 | Macrocyclic Compounds As Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258891-A1 | Macrocyclic Compounds As Antiviral Agents | ZC3HAV1, HAVCR2, ZC3HAV1L | DPP8 884/4885DPP4 515/4885DPP9 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.