Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | ABL1 | P00519 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32660726 | 0.92 | ALDH1A1 (0.70) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL27463994 | 0.85 | POLB (0.69) | MAPTTDP1POLBALDH1A1RAB9A | |
| SCHEMBL27542336 | 0.85 | MAPK1 (0.55) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL8556151 | 0.81 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL23460483 | 0.80 | MAPK1 (0.60) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL1066328 | 0.80 | RAB9A (0.78) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL19970869 | 0.79 | MAPT (0.69) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL27442353 | 0.79 | MAPT (1.00) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL19182181 | 0.78 | RAB9A (1.00) | MAPTTDP1ABL1POLBRIN1 | |
| SCHEMBL4036336 | 0.78 | KMT2A (0.47) | MAPTPOLBALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1136191-C | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists | ������ҩ������˾ | 2004-01-28 | — | — | CN | disclosed |
| CN-1301253-A | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists | AVENTIS PHARMACEUTICAL INC (US) | 2001-06-27 | — | — | CN | disclosed |