Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556151 | 0.81 | MAPT (0.64) | KMT2AMEN1ALDH1A1GAAMAPT | |
| SCHEMBL316881 | 0.79 | LMNA (0.50) | KMT2AMEN1ALDH1A1GAAATM | |
| SCHEMBL316880 | 0.79 | LMNA (0.50) | KMT2AMEN1ALDH1A1GAAATM | |
| SCHEMBL27444507 | 0.78 | MAPT (0.73) | KMT2AALDH1A1GAAMAPTATM | |
| Hydrochloric Acid SCHEMBL1112851 | 0.78 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1GAAMAPT | |
| SCHEMBL2586086 | 0.74 | LMNA (0.52) | KMT2AHRH2HRH1LMNA | |
| SCHEMBL2586090 | 0.74 | LMNA (0.52) | KMT2AHRH2HRH1LMNA | |
| SCHEMBL18608207 | 0.73 | CA1 (0.63) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL4217485 | 0.73 | ALDH1A1 (0.45) | ALDH1A1GAAMAPTLMNAL3MBTL1 | |
| SCHEMBL1742370 | 0.72 | SMN1; SMN2 (0.60) | KMT2AMEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079711-A2 | 2-PHENYL-6-AMINOCARBONYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008050301-A2 | 2- PHENYL- 6-AMINOCARBONYL- PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-02 | — | — | WO | disclosed |