Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.57 |
| ▸ | MMP9 | P14780 | 7/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ITGAV | P06756 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698061 | 0.94 | MMP2 (0.63) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| SCHEMBL6436714 | 0.94 | MMP2 (0.63) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| SCHEMBL698062 | 0.94 | MMP2 (0.63) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| Benzene SCHEMBL28198278 | 0.94 | MMP2 (0.63) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| D-Phenylalanine SCHEMBL8609785 | 0.88 | ALPI (0.63) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| SCHEMBL11471487 | 0.88 | POLB (0.49) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| SCHEMBL16473194 | 0.86 | MMP2 (0.50) | MMP2MMP9ADAMTS4POLBALDH1A1 | |
| SCHEMBL27695660 | 0.85 | ITGB3 (0.60) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| SCHEMBL27677080 | 0.84 | POLB (0.60) | MMP2MMP9ADAMTS4POLBADAMTS5 | |
| SCHEMBL9012465 | 0.84 | MME (0.60) | MMP2MMP9ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1163466-C | Substituted oxobutanoic acid derivatives as matrix metalloproteinase inhibitors | — | 2004-08-25 | — | — | CN | disclosed |
| CN-1139570-C | Inhibition of matrix metalloproteases by acetylene contg. compounds | 拜尔公司 | 2004-02-25 | — | — | CN | disclosed |
| CN-1124255-C | Inhibition of matrix metalloproteases by substituted phenethyl compounds | BAYER AG (US) | 2003-10-15 | — | — | CN | disclosed |
| CN-1119313-C | Inhibition of matrix metalloproteinases by 2- (omega-aroylalkyl) -4-diaryl-4-oxobutanoic acid | BAYER AG (US) | 2003-08-27 | — | — | CN | disclosed |
| CN-1100748-C | Inhibition of matrix metalloproteinases by 2-substituted-4- (4-substituted phenyl) -4-oxobutanoic acid | BAYER AG (US) | 2003-02-05 | — | — | CN | disclosed |
| CN-1234791-A | Inhibition of matrix metalloproteases by 2-('omega'-aroylalkyl)-4-biaryl-oxobutyric acids | BAYER AG (US) | 1999-11-10 | — | — | CN | disclosed |
| CN-1225620-A | Substituted 4-arylbutanoic acid derivatives as matrix metalloproteinase inhibitors | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |
| CN-1225621-A | Inhibition of matrix metalloproteinases by 2-substituted-4- (4-substituted phenyl) -4-oxobutanoic acid | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |
| CN-1225622-A | Substituted oxobutyric acids as matrix metalloprotease inhibitor | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |
| CN-1225624-A | Inhibition of matrix metalloproteases by substituted phenethyl compounds | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |
| CN-1225623-A | Inhibition of matrix metalloproteases by acetylene contg. compounds | BAYER AG (US) | 1999-08-11 | — | — | CN | disclosed |