SCHEMBL27445393

SCHEMBL27445393

CCC(C)c1cc(F)c2c(c1)C(C)(C)N(C)C2=O

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC8 Q9BY41 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12872126 0.66 ALDH1A1 (0.38) HDAC4HDAC2HDAC8
SCHEMBL27445651 0.65 HTR2A (0.30)
SCHEMBL17469351 0.64 ALDH1A1 (0.41) HDAC4HDAC2HDAC8
SCHEMBL13604601 0.63 PTGS1 (0.41) HDAC4HDAC2HDAC8
SCHEMBL25147626 0.63 ADRB2 (0.44) HDAC4HDAC2HDAC8
SCHEMBL21154999 0.63 ALDH1A1 (0.36) HDAC4HDAC2HDAC8
SCHEMBL9908615 0.63 ADRB2 (0.44) HDAC4HDAC2HDAC8
SCHEMBL27445652 0.62 HTR2A (0.30)
SCHEMBL11686432 0.60 ALDH1A1 (0.46) HDAC4HDAC2HDAC8
SCHEMBL24974307 0.60 ALDH1A1 (0.35) HDAC4HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024119122-A1 CDK INHIBITORS AND METHODS AND USE THEREOF RELAY THERAPEUTICS, INC. (US) 2024-06-06 WO disclosed