Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739660 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2MEN1POLB | |
| SCHEMBL28185107 | 0.77 | TSHR (0.47) | MEN1KMT2ACAPN1L3MBTL1TSHR | |
| SCHEMBL1462173 | 0.77 | TSHR (0.58) | ALDH1A1MAPTCAPN1CA1CA2 | |
| SCHEMBL5236516 | 0.75 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2POLBCAPN1 | |
| SCHEMBL8971238 | 0.74 | ALDH1A1 (0.73) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL5237479 | 0.74 | ALDH1A1 (0.55) | ALDH1A1LMNAHTTSMN1; SMN2MEN1 | |
| SCHEMBL27399106 | 0.72 | TSHR (0.59) | ALDH1A1LMNAHTTPOLBMAPT | |
| SCHEMBL5235008 | 0.72 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2MEN1MAPT | |
| SCHEMBL28296921 | 0.71 | HSP90AA1 (0.40) | ALDH1A1L3MBTL1 | |
| SCHEMBL977650 | 0.71 | CAPN1 (0.57) | ALDH1A1LMNASMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1065244-C | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID CO (US) | 2001-05-02 | — | — | CN | disclosed |
| CN-1231666-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1999-10-13 | — | — | CN | disclosed |