Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451638 | 0.85 | MAPT (0.64) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27852729 | 0.83 | RAB9A (0.52) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27452355 | 0.82 | MAPT (0.63) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27452210 | 0.82 | MAPT (0.53) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27452720 | 0.81 | RAB9A (0.77) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27452866 | 0.81 | TP53 (0.60) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27452351 | 0.81 | MAPT (0.77) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27451289 | 0.81 | MAPT (0.53) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27451199 | 0.79 | RAB9A (0.67) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL27452724 | 0.78 | MAPT (0.67) | NPC1RAB9AMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145662-A1 | 2-SUBSTITUTED THIAZOLE AND BENZOTHIAZOLE COMPOSITIONS AND METHODS AS DUX4 INHIBITORS | ALTAY THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |