Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHKA | P35790 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945355 | 0.81 | OPRL1 (0.60) | HRH3KCNH2SMN1; SMN2 | |
| SCHEMBL18906769 | 0.77 | SLC6A4 (0.66) | HRH3KCNH2CHKAMETDAO | |
| SCHEMBL17448255 | 0.77 | HRH3 (0.56) | HRH3KCNH2CHKAMETDAO | |
| SCHEMBL27460493 | 0.77 | TRPA1 (0.40) | HRH3KCNH2CHKAMETOTUD7B | |
| Hydrochloric Acid SCHEMBL17444676 | 0.76 | SLC6A4 (0.64) | HRH3KCNH2CHKAMETDAO | |
| SCHEMBL17444603 | 0.75 | KCNH2 (0.52) | HRH3KCNH2CHKAMETCCR3 | |
| SCHEMBL27459776 | 0.74 | HRH3 (0.48) | HRH3KCNH2CHKAMETDAO | |
| SCHEMBL18889390 | 0.74 | KCNH2 (0.53) | HRH3KCNH2CHKAMETDAO | |
| SCHEMBL4587366 | 0.72 | DRD2 (0.56) | HRH3KCNH2CHKASMN1; SMN2 | |
| SCHEMBL17444664 | 0.72 | KCNH2 (0.48) | HRH3KCNH2CHKAMETABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158276-C | Phenyl-and pyridyl-tetrahydropyridines with TNF inhibiting activity | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1391570-A | Phenyl-and pyridyl-tetrahydro-pyridines having TNF inhibiting activity | SANOFI SYNTHELABO (FR) | 2003-01-15 | — | — | CN | disclosed |